We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses. In vitro studies reported here showed verapamil sensitization of Adriamycin resistance in Patients 27 were first treated with cyclophosphamide, vincristine, Adriamycin and dexamethasone CVAD alone. Verapamil and quinine were added in patients with tumors failing to respond or progressing on CVAD alone.
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Gemcitabine is an anticancer antineoplastic or cytotoxic chemotherapy drug that is intravenously dispensed. It is classified as an antimetabolite drug. Antimetabolites are substances very similar to the normal substances found inside the cell.